What schedule should I follow?
Experts in this area suggest different microdosing regimens, but our microdosing course follows James Fadiman’s system. Fadiman recommends taking a microdose once every three days: Take a microdose on Day 1. Then, do not take a microdose on Day 2 or Day 3. On Day 4, take another microdose.
Continue this process for several weeks.
Paul Stamets recommends a different microdosing protocol—though his method is specifically for psilocybin. He suggests taking a microdose every day for five days, then taking two days off to avoid building up a tolerance.
For most people, morning is the best time because the beneficial effects will last throughout the day without interfering with sleep. It’s also helpful to take daily notes in a journal to observe the effects throughout this process and adjust accordingly—or just notice the positive changes.
It’s also important to follow your usual routine while microdosing. The purpose is to enhance your day-to-day existence by integrating microdoses into your routine, so don’t change what you normally do. However, when you try microdosing for the first time, take a day off from work and social commitments. This will give you a chance to notice any unusual effects before microdosing in a more public situation.
While it may seem like you would only feel the effects of the microdose on the days you actually take it, try to observe the effect on the two days between doses, too. Many people perceive increased feelings of flow, creativity, and energy the day after they microdose in addition to the day of microdosing.
Microdosing San Pedro, peyote, or Peruvian torch every day is not recommended. Those who try it tend to feel jittery and burnt out pretty quickly. Like many psychedelics, mescaline also produces a tolerance effect, which means you’re likely to see diminishing returns within just a few days of daily use. This is one of the reasons why Fadiman recommends taking a couple of days off between each microdose.
Safety is another reason. Although research is limited, there is a potential heart risk associated with frequent psychedelic use over a long period of time—and stimulating phenethylamines like mescaline could actually pose more of a risk. We don’t know what this means for microdosing, but it’s always best to err on the side of caution and stick to Fadiman’s protocol—and for no more than a few months at a time.
Mescaline is a substituted phenethylamine, a molecule based on the basic phenethylamine structure. Along with MDMA, 2C-B, and others, this sets it apart from the tryptamine class of psychedelics, which includes psilocybin, LSD, and DMT. Mescaline activates the serotonin (5-HT) receptors, in particular the 2A receptor subtype.
The science of microdosing
While there has been some recent research on microdosing, we know a lot more about what large doses of psychedelics do to the brain.
Much of what we understand about how psychedelics work involves serotonin, a chemical that is among the brain’s most important neurotransmitters. Serotonin affects nearly everything we do, from how we feel to how we process information. It keeps our brains ticking.
Psychedelics such mescaline share a similar structure to serotonin and mimic the chemical’s effects. This is why these substances have comparable effects to a full dose when microdosed, at least in the most important aspects.
Because serotonin is so important to mood stabilization, common antidepressants (called Selective Serotonin Reuptake Inhibitors, or SSRIs) increase the levels of serotonin in the brain, which can make you feel happier.
Psychedelics work more directly by mimicking serotonin. One of mescaline’s main effects, for example, is to stimulate the 5-HT2A serotonin receptor located in the prefrontal cortex, which leads to two important results:
- The production of “Brain-Derived Neurotrophic Factor” (BDNF), a protein that is “like Miracle-Gro for your brain,” according to author and microdosing proponent Ayelet Waldman. BDNF stimulates growth, connections, and activity. 
- The increased transmission of “Glutamate,” a neurotransmitter responsible (in part) for important brain functions such as cognition, learning, and memory. 
Glutamate and BDNF work together in ways we’ve yet to fully understand, but it’s become clear psychedelics also cause parts of the brain that don’t usually communicate with one another to start talking, so to speak. These unique connections are formed by psychedelics’ ability to dampen the activity of an often overused part of our brain called the “Default Mode Network” (DMN).  The DMN is responsible for many mental activities, including day-dreaming, self-reflection, and thinking about the past or the future.
Research shows that a highly active DMN causes us to ruminate, over-analyze ourselves, and step out of the present moment to question the past and the future, all of which can make us unhappy. In fact, some studies suggest that depression is linked to an overactive DMN.  This helps explain why psychedelics could be used to combat depression and anxiety—as well as lead to insights and creative perspectives that may otherwise remain inaccessible.
BENEFITS & RISK
Many users find mescaline more consistently reliable than LSD and psilocybin and find that the personal benefit can also be greater. Mescaline also has a much longer history of use, and this apparently goes for microdoses too. The Rarámuri Indians, for example, have long used small amounts of peyote while hunting, allowing them to stalk deer for days on end without rest.
Nowadays, self-experimenters around the world are reporting a much wider range of benefits. These include personal insights, mood enhancement, increased empathy and creativity, lifestyle changes, and even lucid dreams.
Some find it useful for treating the symptoms or even the underlying causes of depression, experiencing a sense of peace and calm without the “numbness” of conventional medications. In fact, it tends to have the opposite effect of actually sharpening the senses and enhancing mental clarity. One user remarked on how easy it was to enter a flow state on microdoses of mescaline, especially when playing the guitar:
“I would just be improvising and hit a couple notes that reminded me of a song and then I’d start with those and work my way through the rest of the riff just by memory.” 
Artists in regions where mescaline cacti grow wild are said to microdose for much the same reason.
As might be expected given the traditional Tarahumara use, there’s also a definite stimulant effect, perhaps more so than with LSD or psilocybin. This can be useful for physical endurance such as sports, hiking, manual labor, and so on. And while it may act as an appetite suppressant, mescaline tends to lack the edginess of other stimulants. Indeed some users microdose it specifically to reduce feelings of anxiety, often with great success:
“I … used to have anxiety going to the checkout counter in a store, hated if anyone started small talk with me and planned out what I was going to say to the cashier, it was really bad. After I started taking microdoses of mescaline in the form of San Pedro powder, that all went away.”
Increased empathy may have something to do with this. Many people feel a greater connection to others, for instance, and are often surprised at how freely conversations start to flow.
Mescaline and mescaline-containing cacti are among the safest psychedelics out there with a long history of responsible ceremonial use and not one single case of a fatal overdose. However, there are some potential risks to be aware of, as well as a number of specific contraindications.
Vasoconstriction (the constriction of blood vessels and elevation of blood pressure) may be an issue, particularly during strenuous physical activity, although this is less likely to be a problem with microdosing. For the same reason, it should never be combined with blood pressure medications. In fact, anyone with high blood pressure or heart problems should avoid taking mescaline in general.
Due to the risk of fetal abnormalities and other complications, it should also be avoided by pregnant or breastfeeding women—despite the reputed traditional use of peyote by Huichol women during pregnancy.
Evidence suggests mescaline may be dangerous in combination with a number of other substances, including tramadol, immunomodulators, alcohol, and stimulants.
Also be aware of MAOIs (monoamine oxidase inhibitors), present in some antidepressants (e.g. Marplan, Nardil) and foods containing tyramine (aged cheeses, cured meats, fermented soy products, beer, sauerkraut, etc.). Although not an established contraindication for mescaline, MAOIs could worsen the nausea associated with whole cactus preparations and may even be dangerous in combination.
Mescaline may or may not be safe in combination with cannabis. One user started to shake after smoking weed while microdosing mescaline, which could have something to do with vasoconstriction—although in this case heavy exercise without eating could also have been to blame.
Research into mescaline, and especially its frequent use for microdosing, is limited, which makes this section a work in progress. It’s always a good idea to consult your physician before microdosing any new substance—especially if you have an existing medical condition.
It’s also important to note that not all users find mescaline helps to reduce their anxiety; some find it makes it worse. A few users say it gives them “jittery” feelings and cold sweats or leaves them feeling burnt out, at least when microdosing daily.
Microdosing mescaline could also exacerbate depression in the short term. Similar to MDMA (another phenethylamine), mescaline may produce a slight “comedown” effect in the days after a full dose and potentially a microdose as well. Others have complained of increased light sensitivity and dilated pupils while microdosing mescaline.
Stomach and bowel discomfort is another potential drawback, and may have you rushing to the toilet—but this tends to be associated with whole cactus preparations as opposed to mescaline extracts.
Research into mescaline’s psychotherapeutic potential is still limited (even more so for microdosing) but renewed interest in the drug shows that it could successfully treat mental health disorders. Studies suggest, for example, that mescaline may increase blood flow and activity in the prefrontal cortex, the area of the brain in charge of planning, problem-solving, emotional regulation, and behavior. Low activity in this area is linked to depression and anxiety, leading scientists to hypothesize that mescaline could help alleviate symptoms of these disorders.
Mescaline also activates serotonin and dopamine receptors, which could help boost mood and treat depression. In fact, one of the traditional therapeutic uses for peyote was as an antidepressant, and depression scores are reportedly low among members of the Native American Church, where peyote use is common.
Some researchers have found that the antidepressant benefits of mescaline correlate to a subjects’ willingness to engage with the experience, to face themselves and to act upon the insights received. In one mid-century study, some of the most significant transformations or breakthroughs came about months after the experience itself, even if the initial psychedelic therapy session seemed to be a failure. In the context of psychotherapy, mescaline may also be useful for re-living or recalling repressed memories.
Mescaline could also help reduce suicidal thoughts, according to researchers at the University of Alabama. Using data from the National Survey on Drug Use and Health, the researchers found that people who have used a psychedelic drug at least once in their life show lower rates of suicidal thinking.
A 2013 study also found that lifetime mescaline or peyote use was significantly linked to a lower rate of agoraphobia, an anxiety disorder where subjects perceive their surrounding environment to be threatening.
Addiction is another promising application for mescaline’s therapeutic potential. As peyote, mescaline has long been used in traditional ceremonial contexts to treat alcoholism. It’s interesting to note that while alcohol abuse rates among the Navajo and other Native American tribes are said to be roughly twice the U.S. average, they are significantly lower among NAC members. This correlation isn’t conclusive, of course, but research does suggest that there could be a more-than-causal link. In fact, a researcher at Harvard Medical School who has spent years studying peyote use found that the substance has reduced rates of alcoholism and drug abuse among Native Americans. He also concluded that the ceremonies themselves are an important element to the plant’s healing effects.
In traditional settings, mescaline has been used for alleviating symptoms of fever, headache, sunstroke, and arthritis. Actually the cactus is traditionally seen as something of a cure-all and is sometimes taken daily. According to some Native Americans, the proper use of peyote renders all other medicines superfluous. While there are key differences between modern Western medicine and the medico-religious approach of Native American mystics, clinical studies have supported mescaline’s role in pain relief, and in promoting the release of growth hormones.
Although contemporary psychedelic research tends to overlook mescaline in favor of other substances, it was actually one of the earliest to show true potential as an agent for personal growth.In the 1960s, for example, a team of researchers (including Dr. James Fadiman, author of The Psychedelic Explorer’s Guide) administered up to 200 mg mescaline sulfate to human volunteers and asked them to consider a problem they were facing at work. Some of these problems—which included commercial building and letterhead designs, space probe experiments, and mathematical theorems—had been ongoing for several months. During the experiment, however, almost all participants were able to solve their problem or at least come up with new ways of approaching it.
Another study carried out by Fadiman and others linked guided mescaline therapy sessions to enhanced contentment, creativity, relaxation, and sociability—even after six to nine months had passed.
Most people find also mescaline personally or spiritually transformative, and many emerge with a lasting appreciation for the interconnectedness of all life in the universe, and of their role within it. Sometimes the mere thought of a separate identity can even seem “obscene.” Others feel a deep sense of gratitude and unconditional compassion for everyone and everything around them. Early studies of mescaline also found that the experience left people with a greater sense of wellbeing, inner strength, and vitality.
In line with Native American ritual use of peyote, mescaline can also help people solve sticky problems. In one study, a group of 27 men were given mescaline and asked to think about a problem they were facing at work, some of which had persisted for months. After just one dose, almost every participant either solved the problem for themselves or came up with new ways to approach it. Mescaline may also boost learning capabilities: in another study, researchers found that the substance helped goldfish learn to avoid a shock more quickly. These findings support the prevailing view that mescaline and other psychedelics can enhance creativity.
While none of these studies, nor any since, looked at microdoses of mescaline specifically, their results are certainly promising. And they dovetail not only with what we’ve come to expect from other psychedelics, but also with anecdotal reports.
- deeper connection to source and nature
- deeper meditative states
- positive thinking and mental wellness
- increased intuition, creativity, and focus
- alleviate depression and anxiety
- generating a deep sense of serenity & healing
- Boost Energy
- overcoming addiction
- memory Improvement
***DO NOT CONSUME WITH ANY ANTI-DEPRESSANTS***.
***This is the pure Wachuma Powder (Wachuma Echinopsis) and contains no admixtures that contain Mescaline, so it is 100% Legal and Natural. It is not recommended to take large doses of this in order to facilitate a psychedelic experience. ***
Contraindications: Some people are much more sensitive to the Wachuma Powder in micro dosing pure. If, after micro dosing, you begin to feel anxiety, take a look at the foods you are eating, avoid foods that contain Tyramine such as fermented foods, red wine, etc.
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